Which of the following is a DNA-binding agent?

Epirubicin is classified as a DNA-binding agent, specifically belonging to the anthracycline family of chemotherapy drugs. It works by intercalating into DNA, which disrupts the structure and function of the DNA, ultimately leading to the inhibition of nucleic acid synthesis and inducing apoptosis in cancer cells. This mechanism is critical in the effectiveness of the drug against a variety of cancers, as it directly targets the genetic material within the cells.

In contrast, the other options represent different classes of chemotherapy agents that operate through distinct mechanisms. For instance, paclitaxel is a taxane that stabilizes microtubules and prevents their depolymerization, which is essential for cell division. Vincristine and vindesine are vinca alkaloids that disrupt microtubule formation by binding to tubulin, inhibiting mitosis but not directly interacting with DNA. Therefore, while the other agents are effective in chemotherapy, they do not function as DNA-binding agents like epirubicin does.