When applying ice packs for extravasation treatment, how long should the pack be removed before administering Totect?

The correct duration for removing ice packs before administering Totect is 15 minutes. The rationale behind this timing relates to the balance between providing and alleviating the vasoconstriction effects of the cold. Applying ice packs helps in reducing local blood flow to the area of extravasation, thereby minimizing the spread of the extravasated chemotherapeutic agent and limiting tissue damage.

However, to effectively prepare the tissue for Totect, which is a specific antidote for extravasation of anthracyclines, it's important not to maintain constant cold application. Leaving the ice packs on for too long could hinder the blood flow necessary for Totect to work effectively after administration. Therefore, removing the ice packs for 15 minutes before the administration allows for adequate blood circulation to return to the area, enabling better absorption and effectiveness of the antidote.

This approach ensures that the risk of further complications is minimized while still optimizing the treatment for extravasation injury.