What symptom is commonly associated with venous irritation during chemotherapy infusion?

The symptom commonly associated with venous irritation during chemotherapy infusion is aching and tightness along a peripheral vein. This sensation occurs due to the inflammatory effects of the chemotherapy agents on the venous endothelium, causing irritation along the vein. Patients may describe this feeling as uncomfortable or painful, and it may be localized to the area of the infusion.

While puffiness around the site can occur due to other factors such as fluid retention or extravasation, it is not a definitive symptom of venous irritation. Severe swelling at the site often indicates a more severe reaction, such as infiltration or extravasation, rather than simple venous irritation. Localized fever is not typically associated with venous irritation and is more indicative of an infectious process or systemic response rather than localized vein irritation. Therefore, the discomfort described as aching and tightness is the most characteristic symptom of venous irritation during chemotherapy infusion.