What method is commonly used to prevent hypersensitivity reactions to chemotherapy?

Premedication with antihistamines and corticosteroids is a widely accepted method for preventing hypersensitivity reactions to chemotherapy. This strategy is particularly important for agents that are known to provoke allergic reactions, such as taxanes and certain platinum-based compounds. By administering antihistamines, healthcare providers can help to mitigate symptoms associated with histamine release, such as itching or hives. Corticosteroids are also used to reduce inflammation and provide additional antihistaminic effects, further lowering the risk of an adverse reaction during treatment.

Additionally, the choice to premedicate is supported by clinical guidelines and practice standards, which recommend this approach to enhance patient safety and comfort. In contrast, the other options do not address the need to prevent an immediate reaction effectively or are more related to supportive measures during chemotherapy administration rather than proactive prevention of hypersensitivity. For example, immediate intravenous hydration and continuous monitoring of vital signs are important for patient management but do not inherently reduce the likelihood of hypersensitivity reactions occurring. Administering chemotherapy only at night could potentially influence side effects related to the timing of drug administration but does not specifically target the prevention of hypersensitivity reactions.