What lifestyle factor is associated with an increased risk of colorectal cancer?

Increased alcohol intake is associated with an increased risk of colorectal cancer due to several mechanisms. Alcohol can lead to the formation of toxic metabolites that can damage DNA, promote inflammation, and disrupt the metabolism of folate, which is essential for DNA synthesis and repair. Chronic alcohol consumption may also influence the gut microbiome, leading to changes that could promote carcinogenesis in the colon.

Evidence from numerous epidemiological studies has consistently pointed to a correlation between high levels of alcohol consumption and an elevated risk of developing colorectal cancer. The risk appears to increase with the amount of alcohol consumed, particularly for certain types of alcohol, such as spirits.

In contrast, regular exercise has been linked to a lower risk of a variety of cancers, including colorectal cancer, by promoting healthy body weight and enhancing metabolic health. A low-fat diet and vegan diet are typically associated with health benefits and are not factors that contribute to increased colorectal cancer risk.