What is the recommended dosage of Hyaluronidase for treating extravasation of plant alkaloids?

The recommended dosage of Hyaluronidase for treating extravasation of plant alkaloids is typically 1 ml. Hyaluronidase helps to mitigate the effects of extravasation by breaking down hyaluronic acid in the extracellular matrix, which can improve drug diffusion and facilitate absorption of extravasated substances. In cases of extravasation, particularly with toxic agents like plant alkaloids, the goal is to limit tissue damage and promote healing, which is most effectively achieved with a dosage of 1 ml. This dosage aligns with clinical guidelines and practices that have established the optimal amount for effective treatment while minimizing potential side effects.