What immediate action should be taken if extravasation occurs with Irinotecan?

In the event of extravasation with Irinotecan, flushing the area with sterile water is a crucial immediate action to consider. This is primarily aimed at diluting the drug in the area of extravasation, which can help in minimizing tissue damage by decreasing the concentration of the chemotherapy agent in the surrounding tissue. The mechanical action of flushing may also help to remove as much of the leaked agent as possible from the extravasation site.

Irinotecan is known to cause irritation and potential tissue damage if it escapes into the surrounding tissues. Hence, timely and appropriate management is vital in mitigating these adverse effects. Flushing should ideally be done as part of a broader extravasation management protocol, which may include elevating the affected area and monitoring for further symptoms.

Other options, while they may have their place in the context of extravasation, do not specifically address the immediate need to dilute and remove the drug. Warm compresses might be indicated for other infusional irritants, dexamethasone may be used for its anti-inflammatory properties in other contexts, and analgesics could be necessary for pain management after assessment, but they do not directly address the immediate danger posed by the extravasation of Irinotecan.