If a patient shows signs of an infusion-related hypersensitivity reaction, what should be your first action?

Stopping the paclitaxel infusion immediately is the appropriate first action when a patient exhibits signs of an infusion-related hypersensitivity reaction. This response is crucial because continuing the infusion could exacerbate the patient's condition and lead to more severe reactions, some of which may be life-threatening.

In the case of a hypersensitivity reaction, the goal is to prevent further exposure to the allergen or irritant (in this case, paclitaxel). This action allows for the necessary interventions to begin without the risk of worsening the patient's symptoms. After stopping the infusion, the healthcare team can then assess the patient's symptoms, provide supportive care, and administer appropriate medications like antihistamines or corticosteroids as needed to manage the reaction and its symptoms.

Monitoring vital signs, giving antihistamines, or administering intravenous fluids may be necessary actions following the cessation of the infusion, but these should occur after the immediate step of stopping the drug to prevent further exposure.